New research indicates that individuals who come off new slimming jabs like semaglutide or tirzepatide may regain reduced body mass far faster than those who halt traditional diet and exercise programs.
Research printed in a major health publication demonstrates that while overweight individuals can lose about a fifth of their body weight while using the jabs, the mass is regained at an estimated rate of 0.8 kg per month upon discontinuation.
"Users purchasing such treatments should be informed of the risk of quick rebound weight gain when the treatment ends," warns researcher Dr. Susan Jebb.
This pace of recovery implies a reversion to starting weight in about a year and a half.
Weighing Therapies
The research, which examined dozens of trials involving over 9,000 of participants, contrasted the results of GLP-1 agonists with other pills.
Scientists note that individuals who lose weight through dieting generally have a less rapid creep back—around 0.1 kg a month—post-intervention.
Understanding the Rapid Regain
Doctors propose the mechanism of the jabs accounts for the amplified rebound.
The injections imitate a natural hormone called GLP-1, which helps regulate feelings of fullness.
"Long-term administration of GLP-1 concentrations far above than the body's typical production may cause the body to produce less of its own natural hormone, and could reduce responsiveness to its actions," said Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this GLP-1 'fix' results in appetite is unsuppressed, making excessive eating much more probable."
A Chronic Condition?
The NHS suggest the injections for individuals with weight-linked medical conditions, accompanied by prescribed lifestyle changes.
A number of clinicians contend that, given the high risk of relapse, the treatment might need to be ongoing.
This perspective is echoed by pharmaceutical companies, who note that the findings "emphasize the chronic character of excess weight," akin to managing diseases like diabetes.
Patient Testimonies
Users who have discontinued the jabs describe a intense resurgence of appetite.
"It was like a switch that goes on and you become ravenous," said an individual.
This difficulty is worsened if patients have not adopted sustainable lifestyle or habit modifications during treatment.
Growing Use
Figures show that a significant number of adults in the UK have used these injections in the past year, with interest remaining high.
- Use is more common among females compared to males.
- The middle-aged age group shows the greatest level of interest.
- Many obtain the medications through private healthcare rather than public health services.
Ultimately, clinicians caution that while the jabs are effective agents for shedding pounds, they are not a magic cure and lasting health benefits relies on integrated lifestyle management.
